Dr. Amey Sonavane, MBBS, DNB (General Medicine), DNB (Gastroenterology), MRCP (SCE-Gastroenterology), Fellow in Clinical and Transplant Hepatology, is an consultant in the department of Gastroenterology, Hepatology and Liver transplantation at Apollo Hospitals, Navi Mumbai.
The liver is an organ about the size of a football. It sits just under your rib cage on the right side of your abdomen. The liver is essential for digesting food and ridding your body of toxic substances.
Liver disease can be inherited (genetic). Liver problems can also be caused by a variety of factors that damage the liver, such as viruses, alcohol use and obesity.
Over time, conditions that damage the liver can lead to scarring (cirrhosis), which can lead to liver failure, a life-threatening condition. But early treatment may give the liver time to heal.
Symptoms
Liver disease doesn't always cause noticeable signs and symptoms. If signs and symptoms of liver disease do occur, the may include:
Skin and eyes that appear yellowish (jaundice)
Abdominal pain and swelling
Swelling in the legs and ankles
Itchy skin
Dark urine color
Pale stool color
Chronic fatigue
Nausea or vomiting
Loss of appetite
Tendency to bruise easily
Causes
Liver disease has many causes.
Infection
Parasites and viruses can infect the liver, causing inflammation that reduces liver function. The viruses that cause liver damage can be spread through blood or semen, contaminated food or water, or close contact with a person who is infected. The most common types of liver infection are hepatitis viruses, including:
Hepatitis A
Hepatitis B
Hepatitis C
Immune system abnormality
Diseases in which your immune system attacks certain parts of your body (autoimmune) can affect your liver. Examples of autoimmune liver diseases include:
Autoimmune hepatitis
Primary biliary cholangitis
Primary sclerosing cholangitis
Genetics
An abnormal gene inherited from one or both of your parents can cause various substances to build up in your liver, resulting in liver damage. Genetic liver diseases include:
Hemochromatosis
Wilson's disease
Alpha-1 antitrypsin deficiency
Cancer and other growths
Examples include:
Liver cancer
Bile duct cancer
Liver adenoma
Other
Additional, common causes of liver disease include:
Chronic alcohol abuse
Fat accumulation in the liver (nonalcoholic fatty liver disease)
Certain prescription or over-the-counter medications